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Psoriasis is the speeding up of the usual replacement processes of the
skin. Normally skin cells take about 21-28 days to replace themselves;
in psoriasis this process is greatly accelerated, and skin cells can be
replaced every 2-6 days.
This results in an accumulation of skin cells on the surface of the skin,
in the form of a psoriatic plaque. This process is the same wherever it
occurs on the body. The severity of psoriasis varies greatly from person
to person. For some people it's just a minor irritation, but for others it
has a major impact on quality of life.
Psoriasis is a long-lasting disease (chronic) that can return at any time.
You may have times when you have no symptoms or times when you
have very mild symptoms followed by times where the symptoms are
severe.
What is Psoriasis?
About 2 in 100 people develop psoriasis at some stage of their life. It can first develop at any age, but it most
commonly starts between the ages of 15 and 25. Psoriasis can occur at any point in the lifespan, affecting children,
teenagers, adults and older people. It affects males and females equally.
Psoriasis cannot be caught from other people nor can it be transferred from one part of the body to another.
The exact cause of psoriasis is unknown but it is known that your immune system plays a part.
Your immune system is your body's defense against disease - it produces proteins (antibodies) that attack germs and
viruses.
For some reason, if you have psoriasis, one of these antibodies called T cells start attacking healthy skin cells by
mistake. This triggers other immune responses that cause an increase in the production of new skin cells and also T
cells.
This results in a cycle of skin cell production becoming faster and faster - skin cells are created and then die in the
space of five to six days, rather than the normal 28 days. The dead skin cells then build on the surface of your skin in
thick scaly patches.
Psoriasis runs in families - one in three people with psoriasis has a close relative who also has psoriasis. However, the
exact role that genetics plays in causing psoriasis remains unclear.
There are three genes that are linked to psoriasis- known as SLC9A3R1, NAT9 and RAPTOR. However, a large
proportion of people with these genes never develop skin problems.
Streptococcal throat infections are involved in guttate psoriasis developing, usually in children and young adults.
However, most people with who have streptococcal throat infections do not develop psoriasis.
Diseases of the immune system such as the HIV infection can cause psoriasis to flare up or to appear for the first time.




In most people who have psoriasis, there is no apparent reason why a flare-up develops at any given time.
However, in some people, psoriasis is more likely to flare up in certain situations. These include the following:
Stress -
It is difficult to measure stress and to prove the relationship between stress and psoriasis. However, it is
thought that stress can contribute to a flare up of psoriasis in some people. There is some evidence to suggest
that the treatment of stress in some people with psoriasis may be of benefit.
Infections-
Psoriasis may flare up if you have a feverish illness. In particular, a sore throat caused by a certain type of
bacterium is a cause of guttate psoriasis.
Drugs-
Some drugs and medicines may possibly trigger or worsen psoriasis in some cases. Drugs that have been
suspected of doing this include: beta-blockers (propranolol, atenolol etc), chloroquine, lithium,
anti-inflammatory pain killers (ibuprofen, naproxen, diclofenac, etc), ACE inhibitor drugs, and alcohol. In some
cases the psoriasis may not flare up until the medication has been taken for weeks or months.
Smoking-
Smoking may help to initially trigger psoriasis to develop in some cases. Toxins from cigarette smoke may also
aggravate existing psoriasis.
Trauma-
Injury to the skin, including excessive scratching, may trigger a patch of psoriasis to develop. The development
of psoriatic plaques at a site of injury is known as the Koebner reaction.
Sunlight-
Most people with psoriasis say that sunlight seems to help ease their psoriasis. Many people find that their
psoriasis is less troublesome in the summer months. However, some people notice the opposite with strong
sunlight seeming to make their psoriasis worse. A severe sunburn (which is a skin injury) can also lead to a
flare up of psoriasis.
Hormone Changes-
Psoriasis in women tends to be worst during puberty and during the menopause. These are times when there
are some major changes in female hormone levels. Some pregnant women with psoriasis find that their
symptoms improve when they are pregnant, but it may flare up in the months just after having a baby. Again,
this is thought to be related to changes in hormone levels.
People with psoriasis who establish a daily bath and moisturizing routine will find it not only minimizes scaling but also
helps alleviate itching and keep psoriasis patches looking as good as possible. Make your bath or showers short and
lukewarm, avoid hot water. Hot water feels good at the time, but the itching can rebound worse when you get out.
Moisturize, moisturize, moisturize.
Put moisturizer on your skin 3 to 5 minutes after you towel off after a washing, doing it quickly makes a difference, as
it helps seal in moisture so the skin doesn't get as dry.